Skinbetter Science
Skinbetter Science Canada
Skinbetter Science is a physician-dispensed skincare line built on patented ingredient technology, best known for AlphaRet, a retinoid bonded to an alpha hydroxy acid in a single molecule. Esthetic Skin Solutions is an authorized Canadian retailer of the full range, at Canadian prices, with samples in every order.
Shop the CollectionSkinbetter Science Bestsellers
The products the brand itself calls its physicians' favourites.

Five pillars, four core steps
Skinbetter Science groups its products into five pillars: Retinoids, Antioxidants, Pigmentation, Homeostasis and the Essentials. Most routines start with four of them.
- Cleanse with Cleansing Gel or Refining Foam Cleanser.
- Alto Advanced Defense and Repair Serum in the morning.
- AlphaRet Overnight Cream at night.
- Trio Rebalancing or Trio Luxe Moisture Treatment, morning and night.
Add Even Intensive for the look of uneven tone, Mystro for texture and luminosity, and InterFuse or Techno Neck for expression lines and the neck.
Read the starter routineSkinbetter Science Guides
Which product does what, and which one is yours.
How to Start with Skinbetter Science
The four core steps, what to add next, and what a starter routine costs.
Read the guideAlphaRet, Explained
What bonding a retinoid to an AHA means in practice, and which of the three AlphaRet products to buy.
Read the guideMystro Active Balance vs Mystro Revive
Active Balance for texture, tone and pores. Revive for dry, less firm skin. Most people need one, not both.
Read the guideTrio Rebalancing or Trio Luxe
Two moisturizers that share a name and most of a formula. How to tell which one your skin wants.
Read the guideInterFuse and Techno Neck, Explained
Three products for what a retinoid does not fully answer: expression lines, firmness and the neck.
Read the guideThe full Skinbetter Science collection
Every Skinbetter Science product we carry in Canada, at Canadian prices, with samples in every order.
Shop the collectionAbout the Brand
What is Skinbetter Science?
Skinbetter Science is a physician-dispensed skincare brand built on patented ingredient technology. It is sold through medical and aesthetic clinics and a small number of authorized online retailers, not through pharmacies or department stores. The range covers cleansers, serums, moisturizers, retinoids, eye care and neck care, and is formulated for all skin types, including sensitive skin.
What is AlphaRet?
AlphaRet is Skinbetter Science's patented retinoid technology. It bonds a retinoid to lactic acid, an alpha hydroxy acid, in a single molecule, which the brand describes as delivering retinoid-level results on the look of lines, texture and tone with little to no visible irritation. It is used in AlphaRet Overnight Cream, AlphaRet Clearing Serum and EyeMax AlphaRet Overnight Cream.
Where should I start with Skinbetter Science?
The brand's own physicians' favourites are Alto Advanced Defense and Repair Serum in the morning and AlphaRet Overnight Cream at night, sold together as the A-Team Duo Kit. Add a cleanser and Trio Rebalancing Moisture Treatment and you have the four-step core routine. Our starter routine guide walks through it step by step.
Can I use AlphaRet if I already use another retinol?
Use one retinoid product at a time. If you are switching to AlphaRet from another retinol, finish the one you are on, then start AlphaRet on its own two or three nights a week and build up. Do not layer AlphaRet over another retinol, and keep a broad-spectrum sunscreen in your morning routine every day.
How long does it take to see results?
Skin renews on a roughly 28-day cycle, so most people notice a change in the look of texture and tone within four to six weeks of consistent use. Trio Rebalancing Moisture Treatment is the exception: the brand's own testing reports a visible difference in the look of dryness within two weeks of twice-daily use.
Why is Skinbetter Science packaged in airless pumps?
Most of the range uses airless pump containers, which keep air and fingers away from the formula so the active ingredients stay stable for longer. To activate a new pump, hold it upright, twist the cap to unlock and press a few times until product appears. The pump will not prime upside down.
Clinic skincare, without the clinic visit.
Shop the full Skinbetter Science range at Esthetic Skin Solutions, an authorized Canadian retailer. Samples included with every order.
Shop Skinbetter Science