New at Your Skin Solution · Skin Care Guide · Updated July 2026
ZO Skin Health has reformulated its iconic Growth Factor Serum — and the next-generation version is now available in Canada. Backed by 18+ years of growth factor science, the enhanced formula is clinically shown to improve the appearance of skin density, elasticity, smoothness, and hydration. In the brand's study, skin looked nearly 6 years younger after 8 weeks of use.* Here's what changed, what the clinicals show, and how to use it.
What is Growth Factor Serum?
Growth Factor Serum is ZO Skin Health's advanced anti-aging serum, formulated with synthesized growth factors that support the skin's foundational components and the integrity of its natural extracellular matrix. The next-generation formula targets the visible signs of aging where they show most: loss of density, elasticity, firmness, and smoothness.
- Clinically shown to improve the appearance of skin thickness and elasticity after 8 weeks*
- Helps improve the look of lines and wrinkles, including expression lines
- Supports a restored, supple, hydrated appearance
- Suitable for all skin types — lightweight gel, AM + PM
Key ingredients
- Plant- and enzymatically-derived growth factors — help restore the look of skin density and visible strength
- Dipeptide diaminobutyroyl benzylamide diacetate — helps minimize the appearance of expression lines
- ZPRO® — supports the skin's natural hyaluronic acid replenishment
- Sodium hyaluronate + beta-glucan — support lasting hydration
What the clinical results show
In a 12-week independent, third-party clinical study of 46 women (ages 44–74, Fitzpatrick types I–VI, moderate to severe signs of aging), subjects demonstrated:
- 42% improvement in visible radiance & texture*
- 26% improvement in hydration**
- 16% improvement in elasticity**
- 15% improvement in the appearance of fine lines*
Subject feedback was just as strong: 100% agreed their skin looked lifted, and 98% noted thicker, more cushioned-looking skin.
*Measured by an expert grader. **Instrumental measurements (Cutometer®, Corneometer®). 12-week independent, third-party clinical study, 46 subjects, ages 44–74, Fitzpatrick I–VI, used twice daily with Gentle Cleanser and Sheer Fluid Broad Spectrum Sunscreen SPF 50. "6 years younger" based on an average of subject assessments after 8 weeks. Individual results may vary.
An award-winning formula
The next-generation Growth Factor Serum was named Best Growth Factor in the 2026 Shape Skin Awards — Shape's editor-tested, dermatologist-approved roundup of breakthrough skincare.
Growth Factor Serum vs. Growth Factor Eye Serum
| Growth Factor Serum | Growth Factor Eye Serum | |
|---|---|---|
| Where | Full face + neck | Eye area only |
| Focus | Density, elasticity, lines, hydration | Crow's feet, under-eye texture, puffiness |
| Price (CAD) | $245.00 / 30 ml | $170.00 / 15 ml |
How to use it
After Getting Skin Ready® (cleanse, exfoliate, tone), apply to clean, dry skin morning and night. Layer with your other ZO Prevent + Correct products as directed by your protocol, and always finish your morning routine with a ZO sunscreen. It's TSA-friendly at 30 ml, so it travels well.
Browse the complete lineup on our ZO Skin Health brand page.
FAQ
What's different about the next-generation formula?
The enhanced formulation features next-generation growth factor ingredients, building on 18+ years of ZO growth factor science. It's clinically shown to improve the appearance of skin density, elasticity, smoothness, and hydration.
Is Growth Factor Serum suitable for all skin types?
Yes — the lightweight gel formula is designed for all skin types, used morning and night.
When will I see results?
In ZO's clinical study, skin appeared nearly 6 years younger after 8 weeks of twice-daily use, with measured improvements in radiance, texture, hydration, and elasticity at 12 weeks.* Individual results vary.
Where can I buy ZO Skin Health in Canada?
ZO Skin Health is sold through authorized partners. Your Skin Solution is an authorized Canadian retailer — every bottle is guaranteed authentic, ships from Canada, with free shipping on orders over $100 and samples in every order.
Where to buy Growth Factor Serum in Canada
The next-generation Growth Factor Serum (30 ml, $245.00) is in stock now at Your Skin Solution, Canada's authorized online retailer of medical-grade skincare.